For patients at risk of having children affected by an inherited disease, preimplantation genetic diagnosis, or PGD, is a valuable alternative to conventional prenatal diagnosis by chorionic villus sampling or amniocentesis. Embryos are analysed before implantation, avoiding the uncertainty and trauma associated with diagnosis late in an established pregnancy. This technique may also be useful in the treatment of those couples whom have had recurrent pregnancy loss or recurrent implantation failure.
PGD treatment covers three specific areas:
• Single gene defects
• Human Leukocyte Antigens (HLA) matching
• Chromosomal abnormalities (aneuploidy)
With preimplantation genetic diagnosis, fertile couples have IVF so that early stage embryos are accessible, allowing single cells to be removed by embryo biopsy for genetic analysis and diagnosis before transfer and implantation.
Our genetics counsellor is on hand to offer advice and information to couples during their cycle and beyond.