PGD
Led by Professor Alan Handyside, the ‘father of PGD’, we provide a complete range of PGD services for embryo selection and to avoid inherited disease, with in-house genetic counselling.
Preimplantation Genetic Diagnosis (PGD)
For couples at risk of having children affected by an inherited disease, Preimplantation Genetic Diagnosis (PGD) is a valuable alternative to conventional prenatal diagnosis by chorion villus sampling or amniocentesis, since it avoids the uncertainty and trauma associated with diagnosis late in an established pregnancy. With PGD, fertile couples have in vitro fertilisation (IVF) so that the early embryo is accessible, allowing single cells to be removed by embryo biopsy for genetic analysis and diagnosis before transfer and implantation in the uterus.

Single Gene Defects or HLA Matching
To develop a test for a single gene defect (e.g. Cystic Fibrosis, Marfan Syndrome, Sickle Cell) and HLA matching, we use a technique that combines genetic linkage testing with traditional mutation analysis. Test development can take up to 6 months and will require blood samples from you and your partner and, possibly, additional family members. When test development has been completed, testing of the embryo can take place
Chromosome Imbalance in Translocation Carriers
Test development for chromosomal rearrangements takes from 4-8 weeks and will require
blood samples from you and your partner and, possibly, additional family members. When
test development has been completed, testing of the embryo can take place. If a test was
developed for you more than 6 months ago, it will need to be validated prior to starting your
fertility treatment. For men with a chromosome rearrangement, a sperm translocation test is
recommended to identify the proportion of sperm present with an unbalanced form of the
translocation in a semen sample.
Aneuploidy
Aneuploidy screening is a procedure that screens for the number of chromosomes present in
an embryo. By screening embryos and only transferring those with no identifiable genetic
abnormalities, we aim to reduce the risk of having a child with a chromosome abnormality,
reduce the risk of miscarriage and provide useful diagnostic information regarding the
likelihood of success through IVF treatment.


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